Reduced inspiratory flow attenuates IL‐8 release and MAPK activation of lung overstretch
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چکیده
منابع مشابه
Reduced inspiratory flow attenuates IL-8 release and MAPK activation of lung overstretch.
Lung overstretch involves mechanical factors, including large tidal volumes (VT), which induce inflammatory responses. The current authors hypothesised that inspiratory flow contributes to ventilator-induced inflammation. Buffer-perfused rabbit lungs were ventilated for 2 h with 21%, O2+5%, CO2, positive end-expiratory pressure of 2-3 cmH2O and randomly assigned to either: 1) normal VT (6 mL x ...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2004
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.04.00128703